Hyper-CVAD is a chemotherapy regimen used to treat some forms of leukemia, non-Hodgkin lymphoma (high grade) and lymphoblastic lymphoma.
Hyper-CVAD chemotherapy consists of two combinations of drugs (courses A and B) given an alternating fashion.
'CVAD' is the acronym of the drugs used in course A: cyclophosphamide, vincristine, doxorubicin (also known as Adriamycin), and dexamethasone. Course B consists of methotrexate and cytarabine.
CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of :
- Cyclophosphamide, an alkylating agent which damages DNA by binding to it and causing cross-links
- Hydroxydaunorubicin (also called doxorubicin or Adriamycin), an intercalating agent which damages DNA by inserting itself between DNA bases
- Oncovin (vincristine), which prevents cells from duplicating by binding to the protein tubulin
- Prednisone or prednisolone, which are corticosteroids.
Donating PBSC or marrow
two methods of donation: Peripheral Blood Stem Cells (PBSC) and bone marrow.
Filgrastim is a granulocyte colony-stimulating factor (G-CSF) analog used to stimulate the proliferation and differentiation of granulocytes.[1]] It is produced by recombinant DNA technology.
The Human Leukocyte Antigen (HLA) system is the name of the Major Histocompatibility Complex (MHC) in humans.
